您的位置： 首页 > 产品频道 > 实验室试剂 > PeproTech 100-3 Recombinant Human Heregulinβ-1

PeproTech 100-3 Recombinant Human Heregulinβ-1

PeproTech产品涵盖免疫调节蛋白、白介素、集落刺激因子、生长因子、化学趋化因子、干扰素、脂联素、成纤维生长因子、转化生长因子、肿瘤坏死因子、神经营养素和防御素等诸多生命科学研究领域中重要的生物活性分子。

在线咨询

全国热线

0512-62956104

产品描述/PERFORMANCE

试剂盒_meitu_1

Neuregulin/Heregulin is a family of structurally-related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms releases soluble growth factors. HRG1-β1 contains an Ig domain and an EGF-like domain; the latter is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity that leads to tyrosine phosphorylation. Although HRG1-β1's biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells, which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF). Recombinant Human Heregulinβ-1 (HRG1-B1) is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulinβ-1 (65 amino acid residues).

应用环境/ ENVIRONMENT

细胞凋亡、免疫系统、神经生物学等相关领域

产品说明/ INSTRUCTION

Cat.NO: 100-3

Source:

E.coli
Synonyms:
Neuregulin1 (NRG1-β1), Neu differentiation factor (rat), HRG, HRG1-β1, Breast cancer cell differentiation factor p45, ARIA (Acetylcholine, Receptor Inducing Activity), glial growth factor
AA Sequence:
SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
Purity:
≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
Calculated Molecular Weight:
7.5 kDa
Accession Number:
Q02297
Gene ID:
3084
crossreactivity:
Dog, Human, Mouse, Rat
Country Of Origin: USA
Not for human use.

产品参数/ PARAMETER

10µg

50µg

100µg

250µg

500µg

1mg

: 尊敬的访客：

当您来到这个页面时，您已成为我们最尊贵的客户，beat365官网登录入口真诚欢迎您的到来！

: 联系我们
免费服务电话：0512-62956104十三年专注于生物实验室仪器供应

热品推荐 / Hot product

: 天根试剂-快速质粒小提试剂盒-DP105

天根试剂-快速质粒小提试剂盒-DP105采用硅胶膜吸附技术，结合质粒DNA，操作简单、快速。每次处理1-4ml过夜培养的细菌培养液，仅需8min即可提取多至24μg的质粒DNA。使用本试剂盒提取的质粒DNA可适用于各种常规操作，包括酶切、PCR、测序、连接、转化、文库筛选、体外翻译、转染一些常规的传代细胞等。